Predictive Biology: The Science Behind Our Pet Food

Like most topics these days, pet nutrition has become a little polarizing. With all the trends and changes in pet food, it can be difficult to know who or what to trust. All you want to do is find the best for your dog or cat, so why does it have to be so complicated?

We hear you. At Hill’s, our commitment isn’t in the various trends our competitors are peddling, but in the scientific data gathered from years of ongoing veterinary and nutritional research. Every Hill’s pet food is a collaboration between vets, scientists and pet nutritionists to ensure we are providing the best pet food for your dog or cat.

So, what does all this really mean? Well, it starts with a process called predictive biology. If you’re not a scientist or pet nutritionist, fear not — here’s our process behind making healthy, biology-based pet food products.

Research

Before any dog or cat food ever gets made, we refer to our never-ending study of pet biology. Just like humans, the biology of dogs and cats is the blueprint behind your pet’s life and their roadmap into a fully-grown pet. Learning about a pet’s inner processes, organs, neurological system, blood, reproduction, development, and diseases all prove essential for developing nutrition to optimize their health and well-being.

That’s where predictive biology comes into play — it's a comprehensive approach used to understand your pet's biology. We study how different ingredients and nutrients have an essential role in your pet’s biology and determine how they play a role in their biologic processes. We can break this research into three different areas:

Genetics

As any high school science teacher might explain, genes (made up of DNA) are the code or instructions needed to make the proteins and molecules essential for growth, development and health in all living things. DNA is what controls how big your dog will get, what color your cat will be, what health conditions your pet might be predisposed to, and just about everything else. Studying the genetic makeup of pets allows us to understand what pieces of their DNA are associated with certain traits and what role they play in a dog or cat’s health.

A pet’s DNA plays a huge role in nutrition, too. It influences your pet’s hormones, enzymes, and proteins that help create organs and tissues, digest their food and control their metabolism. Genetic research helps us to determine how a pet will react to certain ingredients and nutrients. This research tells us how your pet will metabolize (break down) certain foods and not others. For instance, genetics is why you can enjoy chocolate as a tasty treat, but it is toxic to a dog or cat.

So, how do we study pet DNA? We begin by taking a swab of a dog or cat’s cheek and look at the cells within the sample. With the help of some sophisticated machines, we are able to extract the DNA from the cells and study it. Through careful mapping, we are able to determine which pieces of a pet’s DNA affects which trait in their biology. 

Genomics

Genomics is the study of how ingredients and nutrients affect the genes of a living organism; in Hill’s case, pets. Different ingredients and nutrients have the ability to change gene’s activity or gene expression, which is why it is so important to study this before ever formulating a pet food.

Think of genomics like a dimmer switch on lights: we observe which nutrients can change the activity of genes in a metabolic pathway either by lowering their activity (dimmer) or increasing their activity (brighter). By studying how genes react to different nutrients, we can determine the biological effects of our pet food formulations. So how do we do this? We can look at effects of ingredients and nutrient on gene expression either in cells in culture in the lab or by feeding the pet.

All of this helps determine which ingredients and nutrients should go into every bag, pouch and can of Hill’s Pet Foods.